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The apical plasma membrane consisting of an array of densely packed microvilli, which are tiny projections intended to increase the surface area for absorption. 107, 163171 (2001). 56, 447467 (2016). Int. The net reaction of bromination follows: To begin removing the impurities, the cholesterol sample (0.97 g) was dissolved in tert-butyl-methyl-ether (7mL). Biochem. Debromination of 473 and 468 was achieved by heating with sodium sulfite in aqueous solution to give 456 (1987ACSA(B)724).The 4,5-dibromo compound 476 was debrominated regioselectively furnishing the 4-bromo compound 473 (1987ACSA(B)724).The regioselectivity reflects that the 5-anion 475 according to H/D exchange rates is formed faster than the 4-anion 474 (Scheme 138). Chang, C. C. Y. et al. Mol. Tveten, K. et al. Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. 119, 827838 (2016). Thekey factors governing these pathways and the major mechanisms by which they respond tovarying sterol levels are described. Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism.

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